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Gamma secretase activating protein is a substrate for caspase-3: implications for Alzheimer’s disease
BACKGROUND: A major hallmark feature of Alzheimer’s disease (AD) is the accumulation of amyloid β (Aβ), whose formation is regulated by the γ-secretase complex and its activating protein (also known as GSAP). Because GSAP interacts with the γ-secretase without affecting the cleavage of Notch, it is...
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| 發表在: | Biol Psychiatry |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4268092/ https://ncbi.nlm.nih.gov/pubmed/25052851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2014.06.003 |
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