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Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway
A major hallmark feature of Alzheimer’s disease (AD) is the accumulation of amyloid β (Aβ), whose formation is regulated by the γ-secretase complex and its activating protein (also known as γ-secretase activating protein, or GSAP). Because GSAP interacts with the γ-secretase without affecting the cl...
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| Veröffentlicht in: | J Neurochem |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4397152/ https://ncbi.nlm.nih.gov/pubmed/25533523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13011 |
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