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Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway

A major hallmark feature of Alzheimer’s disease (AD) is the accumulation of amyloid β (Aβ), whose formation is regulated by the γ-secretase complex and its activating protein (also known as γ-secretase activating protein, or GSAP). Because GSAP interacts with the γ-secretase without affecting the cl...

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Vydáno v:J Neurochem
Hlavní autoři: Chu, Jin, Li, Jian-Guo, Hoffman, Nicholas E., Madesh, Muniswamy, Praticò, Domenico
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397152/
https://ncbi.nlm.nih.gov/pubmed/25533523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13011
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