K-Ras Promotes Angiogenesis Mediated by Immortalized Human Pancreatic Epithelial Cells through Mitogen-Activated Protein Kinase Signaling Pathways

Activating point mutations in the K-Ras oncogene are among the most common genetic alterations in pancreatic cancer, occurring early in the progression of the disease. However, the function of mutant K-Ras activity in tumor angiogenesis remains poorly understood. Using human pancreatic duct epitheli...

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Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Matsuo, Yoichi, Campbell, Paul M., Brekken, Rolf A., Sung, Bokyung, Ouellette, Michel M., Fleming, Jason B., Aggarwal, Bharat B., Der, Channing J., Guha, Sushovan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267726/
https://ncbi.nlm.nih.gov/pubmed/19509115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0577
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