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The interface between transcriptional and epigenetic control of effector and memory CD8(+) T-cell differentiation

Immunity to many intracellular pathogens requires the proliferation, differentiation, and function of CD8(+) cytotoxic T lymphocytes (CTLs). While the majority of effector CTLs die upon clearance of the pathogen, a small proportion of them survive to become long-lived memory CTLs. Memory CTLs can pr...

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Bibliographic Details
Published in:Immunol Rev
Main Authors: Gray, Simon M., Kaech, Susan M., Staron, Matthew M.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267690/
https://ncbi.nlm.nih.gov/pubmed/25123283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imr.12205
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