Loss of loop adenines alters human telomere d[AG(3)(TTAG(3))(3)] quadruplex folding

Abasic (AP) lesions are the most frequent type of damages occurring in cellular DNA. Here we describe the conformational effects of AP sites substituted for 2′-deoxyadenosine in the first (ap7), second (ap13) or third (ap19) loop of the quadruplex formed in K(+) by the human telomere DNA 5′-d[AG(3)(...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Babinský, Martin, Fiala, Radovan, Kejnovská, Iva, Bednářová, Klára, Marek, Radek, Sagi, Janos, Sklenář, Vladimír, Vorlíčková, Michaela
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2014
Pynciau:
Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267657/
https://ncbi.nlm.nih.gov/pubmed/25428355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1245
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