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Clustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes

Ionizing radiation produces clustered damage to DNA which is difficult to repair and thus more harmful than single lesions. Clustered lesions have only been investigated in dsDNA models. Introducing the term ‘clustered damage to G-quadruplexes’ we report here on the structural effects of multiple te...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Kejnovská, Iva, Bednářová, Klára, Renčiuk, Daniel, Dvořáková, Zuzana, Školáková, Petra, Trantírek, Lukáš, Fiala, Radovan, Vorlíčková, Michaela, Sagi, Janos
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416849/
https://ncbi.nlm.nih.gov/pubmed/28369584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx191
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