Clustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes

Ionizing radiation produces clustered damage to DNA which is difficult to repair and thus more harmful than single lesions. Clustered lesions have only been investigated in dsDNA models. Introducing the term ‘clustered damage to G-quadruplexes’ we report here on the structural effects of multiple te...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Kejnovská, Iva, Bednářová, Klára, Renčiuk, Daniel, Dvořáková, Zuzana, Školáková, Petra, Trantírek, Lukáš, Fiala, Radovan, Vorlíčková, Michaela, Sagi, Janos
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Chemical Biology and Nucleic Acid Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416849/
https://ncbi.nlm.nih.gov/pubmed/28369584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx191
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