Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia

Cell fate can be controlled through asymmetric division and segregation of protein determinants. But the regulation of this process in the hematopoietic system is poorly understood. Here we show that the dynein binding protein Lis1 (Pafah1b1) is critically required for blood formation and hematopoie...

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Bibliographic Details
Published in:Nat Genet
Main Authors: Zimdahl, Bryan, Ito, Takahiro, Blevins, Allen, Bajaj, Jeevisha, Konuma, Takaaki, Weeks, Joi, Koechlein, Claire S., Kwon, Hyog Young, Arami, Omead, Rizzieri, David, Broome, H. Elizabeth, Chuah, Charles, Oehler, Vivian G., Sasik, Roman, Hardiman, Gary, Reya, Tannishtha
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267534/
https://ncbi.nlm.nih.gov/pubmed/24487275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2889
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