Substrate recognition by the cell surface palmitoyl transferase DHHC5

The cardiac phosphoprotein phospholemman (PLM) regulates the cardiac sodium pump, activating the pump when phosphorylated and inhibiting it when palmitoylated. Protein palmitoylation, the reversible attachment of a 16 carbon fatty acid to a cysteine thiol, is catalyzed by the Asp-His-His-Cys (DHHC)...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Howie, Jacqueline, Reilly, Louise, Fraser, Niall J., Vlachaki Walker, Julia M., Wypijewski, Krzysztof J., Ashford, Michael L. J., Calaghan, Sarah C., McClafferty, Heather, Tian, Lijun, Shipston, Michael J., Boguslavskyi, Andrii, Shattock, Michael J., Fuller, William
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267385/
https://ncbi.nlm.nih.gov/pubmed/25422474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413627111
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