CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation

We used a genome-wide screen in mutagenized mice to identify genes which inactivation protects against lethal neuroinflammation during experimental cerebral malaria (ECM). We identified an ECM-protective mutation in coiled-coil domain containing protein 88b (Ccdc88b), a poorly annotated gene that is...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Kennedy, James M., Fodil, Nassima, Torre, Sabrina, Bongfen, Silayuv E., Olivier, Jean-Frédéric, Leung, Vicki, Langlais, David, Meunier, Charles, Berghout, Joanne, Langat, Pinky, Schwartzentruber, Jeremy, Majewski, Jacek, Lathrop, Mark, Vidal, Silvia M., Gros, Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267237/
https://ncbi.nlm.nih.gov/pubmed/25403443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140455
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