Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

Age-related aggregation of amyloid-β (Aβ) is an upstream pathological event in Alzheimer’s disease (AD) pathogenesis, and it disrupts the sleep–wake cycle. The amount of sleep declines with aging and to a greater extent in AD. Poor sleep quality and insufficient amounts of sleep have been noted in h...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Roh, Jee Hoon, Jiang, Hong, Finn, Mary Beth, Stewart, Floy R., Mahan, Thomas E., Cirrito, John R., Heda, Ashish, Snider, B. Joy, Li, Mingjie, Yanagisawa, Masashi, de Lecea, Luis, Holtzman, David M.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
Fag:
Brief Definitive Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267230/
https://ncbi.nlm.nih.gov/pubmed/25422493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141788
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