The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double strand break repair

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ataxia telangiectasia mutated (ATM) are the two major kinases involved in DNA double-strand break (DSB) repair, and are required for cellular resistance to ionizing radiation. While ATM is the key upstream kinase for DSB signaling, DNA-PK...

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Enregistré dans:
Détails bibliographiques
Publié dans:Free Radic Biol Med
Auteurs principaux: Li, Mengxia, Lin, Yu-Fen, Palchik, Guillermo, Matsunaga, Shinji, Wang, Dong, Chen, Benjamin P.C.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267055/
https://ncbi.nlm.nih.gov/pubmed/25224041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.08.019
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