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PCI-24781 (abexinostat), a novel histone deacetylase inhibitor, induces reactive oxygen species-dependent apoptosis and is synergistic with bortezomib in neuroblastoma

In this study, we investigated the cytotoxic effects of a broad-spectrum histone deacetylase (HDAC) inhibitor, PCI-24781, alone and in combination with the proteasome inhibitor bortezomib in neuroblastoma cell lines. The combination was shown to induce synergistic cytotoxity involving the formation...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cancer Ther Res
Egile Nagusiak: Sholler, Giselle Saulnier, Currier, Erika A., Dutta, Akshita, Slavik, Marni A., Illenye, Sharon A., Mendonca, Maria Cecilia F., Dragon, Julie, Roberts, Stephen S., Bond, Jeffrey P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266584/
https://ncbi.nlm.nih.gov/pubmed/25520806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7243/2049-7962-2-21
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