Intranasal Administration of Mycobacterium bovis BCG Induces Superior Protection against Aerosol Infection with Mycobacterium tuberculosis in Mice

Despite the widespread use of Mycobacterium bovis BCG, the only licensed vaccine against tuberculosis (TB), TB remains a global epidemic. To assess whether more direct targeting of the lung mucosa by respiratory immunization would enhance the potency and longevity of BCG-induced anti-TB protective i...

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Bibliographic Details
Published in:Clin Vaccine Immunol
Main Authors: Derrick, Steven C., Kolibab, Kristopher, Yang, Amy, Morris, Sheldon L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266354/
https://ncbi.nlm.nih.gov/pubmed/25143340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00394-14
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