Formulation of a mmaA4 Gene Deletion Mutant of Mycobacterium bovis BCG in Cationic Liposomes Significantly Enhances Protection against Tuberculosis

A new vaccination strategy is urgently needed for improved control of the global tuberculosis (TB) epidemic. Using a mouse aerosol Mycobacterium tuberculosis challenge model, we investigated the protective efficacy of a mmaA4 gene deletion mutant of Mycobacterium bovis BCG (ΔmmaA4BCG) formulated in...

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Detalhes bibliográficos
Main Authors: Derrick, Steven C., Dao, Dee, Yang, Amy, Kolibab, Kris, Jacobs, William R., Morris, Sheldon L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307709/
https://ncbi.nlm.nih.gov/pubmed/22442674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032959
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