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Crystal Structure of Sphingosine Kinase 1 with PF-543
[Image: see text] The most potent inhibitor of Sphingosine Kinase 1 (SPHK1) so far identified is PF-543. The crystal structure of SPHK1 in complex with inhibitor PF-543 to 1.8 Å resolution reveals the inhibitor bound in a bent conformation analogous to that expected of a bound sphingosine substrate...
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| Izdano u: | ACS Med Chem Lett |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2014
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| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4265818/ https://ncbi.nlm.nih.gov/pubmed/25516793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5004074 |
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