HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

Cellular senescence is a stable proliferation arrest that suppresses tumorigenesis. Cellular senescence and associated tumor suppression depend on control of chromatin. Histone chaperone HIRA deposits variant histone H3.3 and histone H4 into chromatin in a DNA replication-independent manner. Appropr...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Rai, Taranjit Singh, Cole, John J., Nelson, David M., Dikovskaya, Dina, Faller, William J., Vizioli, Maria Grazia, Hewitt, Rachael N., Anannya, Orchi, McBryan, Tony, Manoharan, Indrani, van Tuyn, John, Morrice, Nicholas, Pchelintsev, Nikolay A., Ivanov, Andre, Brock, Claire, Drotar, Mark E., Nixon, Colin, Clark, William, Sansom, Owen J., Anderson, Kurt I., King, Ayala, Blyth, Karen, Adams, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265675/
https://ncbi.nlm.nih.gov/pubmed/25512559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.247528.114
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