HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

Cellular senescence is a stable proliferation arrest that suppresses tumorigenesis. Cellular senescence and associated tumor suppression depend on control of chromatin. Histone chaperone HIRA deposits variant histone H3.3 and histone H4 into chromatin in a DNA replication-independent manner. Appropr...

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Vydáno v:Genes Dev
Hlavní autoři: Rai, Taranjit Singh, Cole, John J., Nelson, David M., Dikovskaya, Dina, Faller, William J., Vizioli, Maria Grazia, Hewitt, Rachael N., Anannya, Orchi, McBryan, Tony, Manoharan, Indrani, van Tuyn, John, Morrice, Nicholas, Pchelintsev, Nikolay A., Ivanov, Andre, Brock, Claire, Drotar, Mark E., Nixon, Colin, Clark, William, Sansom, Owen J., Anderson, Kurt I., King, Ayala, Blyth, Karen, Adams, Peter D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265675/
https://ncbi.nlm.nih.gov/pubmed/25512559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.247528.114
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