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Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner
The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis. Here, we demonstrate that the deubiquitinase Cezanne regulates HIF-1α homeostasis. Loss of Cezanne decreases...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4264929/ https://ncbi.nlm.nih.gov/pubmed/25355043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438850 |
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