Regulation of Adenosine 3′:5′-Cyclic Monophosphate Phosphodiesterase Activity in Fibroblasts by Intracellular Concentrations of Cyclic Adenosine Monophosphate

Cyclic AMP-phosphodiesterase is present in various mouse fibroblasts. Contact-inhibited 3T3 cells contain two forms of the enzyme, one with a K(m) of 2.5 μM and the second with a K(m) of 71 μM. As 3T3 cells grow to confluency and cAMP concentrations rise, the activity of the first enzyme increases,...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	D'Armiento, Massimo, Johnson, George S., Pastan, Ira
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1972
Schlagworte:	Biological Sciences: Biochemistry
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC426480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4333987/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.69.2.459
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