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Multiple Mechanisms Mediate Resistance to Sorafenib in Urothelial Cancer

Genetic and epigenetic changes in the mitogen activated protein kinase (MAPK) signaling render urothelial cancer a potential target for tyrosine kinase inhibitor (TKI) treatment. However, clinical trials of several TKIs failed to prove efficacy. In this context, we investigated changes in MAPK signa...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Knievel, Judith, Schulz, Wolfgang A., Greife, Annemarie, Hader, Christiane, Lübke, Tobias, Schmitz, Ingo, Albers, Peter, Niegisch, Günter
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264180/
https://ncbi.nlm.nih.gov/pubmed/25387078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms151120500
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