Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging human pathogen that was first isolated in 2012. MERS-CoV replication depends in part on a virus-encoded papain-like protease (PL(pro)) that cleaves the viral replicase polyproteins at three sites releasing non-structural pro...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Bailey-Elkin, Ben A., Knaap, Robert C. M., Johnson, Garrett G., Dalebout, Tim J., Ninaber, Dennis K., van Kasteren, Puck B., Bredenbeek, Peter J., Snijder, Eric J., Kikkert, Marjolein, Mark, Brian L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263872/
https://ncbi.nlm.nih.gov/pubmed/25320088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609644
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