Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging human pathogen that was first isolated in 2012. MERS-CoV replication depends in part on a virus-encoded papain-like protease (PL(pro)) that cleaves the viral replicase polyproteins at three sites releasing non-structural pro...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bailey-Elkin, Ben A., Knaap, Robert C. M., Johnson, Garrett G., Dalebout, Tim J., Ninaber, Dennis K., van Kasteren, Puck B., Bredenbeek, Peter J., Snijder, Eric J., Kikkert, Marjolein, Mark, Brian L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263872/
https://ncbi.nlm.nih.gov/pubmed/25320088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609644
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