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The Emerging Link between O-GlcNAc and Alzheimer Disease

Regional glucose hypometabolism is a defining feature of Alzheimer disease (AD). One emerging link between glucose hypometabolism and progression of AD is the nutrient-responsive post-translational O-GlcNAcylation of nucleocytoplasmic proteins. O-GlcNAc is abundant in neurons and occurs on both tau...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhu, Yanping, Shan, Xiaoyang, Yuzwa, Scott A., Vocadlo, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263855/
https://ncbi.nlm.nih.gov/pubmed/25336656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R114.601351
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