Metabolic Inhibitors of O‐GlcNAc Transferase That Act In Vivo Implicate Decreased O‐GlcNAc Levels in Leptin‐Mediated Nutrient Sensing

O‐Linked glycosylation of serine and threonine residues of nucleocytoplasmic proteins with N‐acetylglucosamine (O‐GlcNAc) residues is catalyzed by O‐GlcNAc transferase (OGT). O‐GlcNAc is conserved within mammals and is implicated in a wide range of physiological processes. Herein, we describe metabo...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Angew Chem Int Ed Engl
Päätekijät: Liu, Tai‐Wei, Zandberg, Wesley F., Gloster, Tracey M., Deng, Lehua, Murray, Kelsey D., Shan, Xiaoyang, Vocadlo, David J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2018
Aiheet:
Communications
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055616/
https://ncbi.nlm.nih.gov/pubmed/29756380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803254
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