11-TRIFLUOROMETHYL-PHENYLDIAZIRINYL NEUROSTEROID ANALOGUES: POTENT GENERAL ANESTHETICS AND PHOTOLABELING REAGENTS FOR GABA(A) RECEPTORS

RATIONALE: While neurosteroids are well-described positive allosteric modulators of GABA(A) receptors, the binding sites that mediate these actions have not been definitively identified. OBJECTIVES: To synthesize neurosteroid analogue photolabeling reagents that closely mimic the biological effects...

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Vydáno v:Psychopharmacology (Berl)
Hlavní autoři: Chen, Zi-Wei, Wang, Cunde, Krishnan, Kathiresan, Manion, Brad D., Hastings, Randy, Bracamontes, John, Taylor, Amanda, Eaton, Megan M., Zorumski, Charles F., Steinbach, Joseph H., Akk, Gustav, Mennerick, Steven, Covey, Douglas F., Evers, Alex S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263769/
https://ncbi.nlm.nih.gov/pubmed/24756762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3568-4
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