Hypercytotoxicity and Rapid Loss of NKp44(+) Innate Lymphoid Cells during Acute SIV Infection

HIV/SIV infections break down the integrity of the gastrointestinal mucosa and lead to chronic immune activation and associated disease progression. Innate lymphoid cells (ILCs), distinguishable by high expression of NKp44 and RORγt, play key roles in mucosal defense and homeostasis, but are deplete...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Li, Haiying, Richert-Spuhler, Laura E., Evans, Tristan I., Gillis, Jacqueline, Connole, Michelle, Estes, Jacob D., Keele, Brandon F., Klatt, Nichole R., Reeves, R. Keith
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263758/
https://ncbi.nlm.nih.gov/pubmed/25503264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004551
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