Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44(+) mucosal NK cells during SIV infection

Natural killer (NK) cells are classically viewed as effector cells that kill virus-infected and neoplastic cells, but recent studies have identified a rare mucosal NK- cell subpopulation secreting the TH17 cytokine IL-22. Here, we report identification of 2 distinct lineages of mucosal NK cells char...

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Hlavní autoři: Reeves, R. Keith, Rajakumar, Premeela A., Evans, Tristan I., Connole, Michelle, Gillis, Jacqueline, Wong, Fay E., Kuzmichev, Yury V., Carville, Angela, Johnson, R. Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2011
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179400/
https://ncbi.nlm.nih.gov/pubmed/21791421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-347260
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