Oligonucleotides conjugated with short chemically defined polyethylene glycol chains are efficient antisense agents

Ligand conjugation is an attractive approach to rationally modify the poor pharmacokinetic behavior and cellular uptake properties of antisense oligonucleotides. Polyethylene glycol (PEG) attachment is a method to increase solubility of oligonucleotides and prevent the rapid elimination, thus increa...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Shokrzadeh, Nasrin, Winkler, Anna-Maria, Dirin, Mehrdad, Winkler, Johannes
Format: Artigo
Language:Inglês
Published: Elsevier Science Ltd 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263527/
https://ncbi.nlm.nih.gov/pubmed/25453815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.10.045
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