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Oligonucleotides conjugated with short chemically defined polyethylene glycol chains are efficient antisense agents
Ligand conjugation is an attractive approach to rationally modify the poor pharmacokinetic behavior and cellular uptake properties of antisense oligonucleotides. Polyethylene glycol (PEG) attachment is a method to increase solubility of oligonucleotides and prevent the rapid elimination, thus increa...
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| Publié dans: | Bioorg Med Chem Lett |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier Science Ltd
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4263527/ https://ncbi.nlm.nih.gov/pubmed/25453815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.10.045 |
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