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Oligonucleotide conjugates for therapeutic applications
Insufficient pharmacokinetic properties and poor cellular uptake are the main hurdles for successful therapeutic development of oligonucleotide agents. The covalent attachment of various ligands designed to influence the biodistribution and cellular uptake or for targeting specific tissues is an att...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3787477/ https://ncbi.nlm.nih.gov/pubmed/23883124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/tde.13.47 |
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