Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants

We demonstrate that the purified Staphylococcus aureus extracellular proteases aureolysin, ScpA, SspA, and SspB limit biofilm formation, with aureolysin having the greatest impact. Using protease-deficient derivatives of LAC, we confirmed that this is due to the individual proteases themselves. Puri...

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Detalhes bibliográficos
Publicado no:Microbiologyopen
Main Authors: Loughran, Allister J, Atwood, Danielle N, Anthony, Allison C, Harik, Nada S, Spencer, Horace J, Beenken, Karen E, Smeltzer, Mark S
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263513/
https://ncbi.nlm.nih.gov/pubmed/25257373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mbo3.214
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