Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

Protein folding in the cell relies on the orchestrated action of conserved families of molecular chaperones, the Hsp70 and Hsp90 systems. Hsp70 acts early and Hsp90 late in the folding path, yet the molecular basis of this timing is enigmatic, mainly because the substrate specificity of Hsp90 is poo...

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Veröffentlicht in:Cell
Hauptverfasser: Karagöz, G. Elif, Duarte, Afonso M.S., Akoury, Elias, Ippel, Hans, Biernat, Jacek, Luengo, Tania Morán, Radli, Martina, Didenko, Tatiana, Nordhues, Bryce A., Veprintsev, Dmitry B., Dickey, Chad A., Mandelkow, Eckhard, Zweckstetter, Markus, Boelens, Rolf, Madl, Tobias, Rüdiger, Stefan G.D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263503/
https://ncbi.nlm.nih.gov/pubmed/24581495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.037
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