Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

Sphingosine is a major storage compound in Niemann–Pick type C disease (NP–C), although the pathological role(s) of this accumulation have not been fully characterized. Here we found that sphingosine kinase (SphK) activity is reduced in NP–C patient fibroblasts and NP–C mouse Purkinje neurons (PNs)...

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發表在:Nat Commun
Main Authors: Lee, Hyun, Lee, Jong Kil, Park, Min Hee, Hong, Yu Ri, Marti, Hugo H., Kim, Hyongbum, Okada, Yohei, Otsu, Makoto, Seo, Eul-Ju, Park, Jae-Hyung, Bae, Jae-Hoon, Okino, Nozomu, He, Xingxuan, Schuchman, Edward H., Bae, Jae-sung, Jin, Hee Kyung
格式: Artigo
語言:Inglês
出版: Nature Pub. Group 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263144/
https://ncbi.nlm.nih.gov/pubmed/25417698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6514
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