Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

Sphingosine is a major storage compound in Niemann–Pick type C disease (NP–C), although the pathological role(s) of this accumulation have not been fully characterized. Here we found that sphingosine kinase (SphK) activity is reduced in NP–C patient fibroblasts and NP–C mouse Purkinje neurons (PNs)...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Lee, Hyun, Lee, Jong Kil, Park, Min Hee, Hong, Yu Ri, Marti, Hugo H., Kim, Hyongbum, Okada, Yohei, Otsu, Makoto, Seo, Eul-Ju, Park, Jae-Hyung, Bae, Jae-Hoon, Okino, Nozomu, He, Xingxuan, Schuchman, Edward H., Bae, Jae-sung, Jin, Hee Kyung
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Pub. Group 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263144/
https://ncbi.nlm.nih.gov/pubmed/25417698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6514
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