Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

Sphingosine is a major storage compound in Niemann–Pick type C disease (NP–C), although the pathological role(s) of this accumulation have not been fully characterized. Here we found that sphingosine kinase (SphK) activity is reduced in NP–C patient fibroblasts and NP–C mouse Purkinje neurons (PNs)...

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Foilsithe in:Nat Commun
Main Authors: Lee, Hyun, Lee, Jong Kil, Park, Min Hee, Hong, Yu Ri, Marti, Hugo H., Kim, Hyongbum, Okada, Yohei, Otsu, Makoto, Seo, Eul-Ju, Park, Jae-Hyung, Bae, Jae-Hoon, Okino, Nozomu, He, Xingxuan, Schuchman, Edward H., Bae, Jae-sung, Jin, Hee Kyung
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Pub. Group 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263144/
https://ncbi.nlm.nih.gov/pubmed/25417698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6514
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