Positron emission tomography and functional characterization of a complete PBR/TSPO knockout

The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa translocator protein (TSPO), is thought to be essential for cholesterol transport and steroidogenesis, and thus life. TSPO has been proposed as a biomarker of neuroinflammation and a new drug target in neurological dise...

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Publié dans:Nat Commun
Auteurs principaux: Banati, Richard B., Middleton, Ryan J., Chan, Ronald, Hatty, Claire R., Wai-Ying Kam, Winnie, Quin, Candice, Graeber, Manuel B., Parmar, Arvind, Zahra, David, Callaghan, Paul, Fok, Sandra, Howell, Nicholas R., Gregoire, Marie, Szabo, Alexander, Pham, Tien, Davis, Emma, Liu, Guo-Jun
Format: Artigo
Langue:Inglês
Publié: Nature Pub. Group 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263137/
https://ncbi.nlm.nih.gov/pubmed/25406832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6452
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