Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes

Perforin-mediated cytotoxicity is an essential host defense, in which defects contribute to tumor development and pathogenic disorders including autoimmunity and autoinflammation. How perforin (PFN) facilitates intracellular delivery of pro-apoptotic and inflammatory granzymes across the bilayer of...

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Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: Metkar, S S, Marchioretto, M, Antonini, V, Lunelli, L, Wang, B, Gilbert, R JC, Anderluh, G, Roth, R, Pooga, M, Pardo, J, Heuser, J E, Serra, M D, Froelich, C J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262768/
https://ncbi.nlm.nih.gov/pubmed/25146929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.110
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