Perforin activity at membranes leads to invaginations and vesicle formation

The cytotoxic cell granule secretory pathway is essential for immune defence. How the pore-forming protein perforin (PFN) facilitates the cytosolic delivery of granule-associated proteases (granzymes) remains enigmatic. Here we show that PFN is able to induce invaginations and formation of complete...

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Detalhes bibliográficos
Main Authors: Praper, Tilen, Sonnen, Andreas F.-P., Kladnik, Aleš, Andrighetti, Alberto O., Viero, Gabriella, Morris, Keith J., Volpi, Emanuela, Lunelli, Lorenzo, Serra, Mauro Dalla, Froelich, Christopher J., Gilbert, Robert J. C., Anderluh, Gregor
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248536/
https://ncbi.nlm.nih.gov/pubmed/22173634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107473108
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