Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy

BACKGROUND AND PURPOSE: Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Resistance to insulin, the major abnormality in type 2 diabetes, results in a decreased GLUT4 translocation efficiency. Thus,...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Lanzerstorfer, Peter, Stadlbauer, Verena, Chtcheglova, Lilia A, Haselgrübler, Renate, Borgmann, Daniela, Wruss, Jürgen, Hinterdorfer, Peter, Schröder, Klaus, Winkler, Stephan M, Höglinger, Otmar, Weghuber, Julian
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2014
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262000/
https://ncbi.nlm.nih.gov/pubmed/25039620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12845
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