Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy

BACKGROUND AND PURPOSE: Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Resistance to insulin, the major abnormality in type 2 diabetes, results in a decreased GLUT4 translocation efficiency. Thus,...

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Udgivet i:Br J Pharmacol
Main Authors: Lanzerstorfer, Peter, Stadlbauer, Verena, Chtcheglova, Lilia A, Haselgrübler, Renate, Borgmann, Daniela, Wruss, Jürgen, Hinterdorfer, Peter, Schröder, Klaus, Winkler, Stephan M, Höglinger, Otmar, Weghuber, Julian
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262000/
https://ncbi.nlm.nih.gov/pubmed/25039620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12845
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