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Detection of the secondary, low-affinity β(1)-adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP
BACKGROUND AND PURPOSE: CGP 12177 not only inhibits agonist effects mediated through the catecholamine site of the β(1)-adrenoceptor with high affinity, but also exhibits agonist effects of its own at higher concentrations through a secondary, low-affinity β(1)-adrenoceptor site or conformation. β-b...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4261997/ https://ncbi.nlm.nih.gov/pubmed/25052258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12858 |
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