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Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure

OBJECTIVE: Hyperoxia exposure leads to the development of lung injury and bronchial hyperreactivity (BHR) via involvement of nitric oxide (NO) pathway. We aimed at characterizing whether the stimulation of the NO pathway by sildenafil or vasoactive intestinal peptide (VIP) is able to prevent the hyp...

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Pubblicato in:Respir Res
Autori principali: Czövek, Dorottya, Peták, Ferenc, Donati, Yves, Belin, Xavier, Pache, Jean-Claude, Barazzone Argiroffo, Constance, Habre, Walid
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261898/
https://ncbi.nlm.nih.gov/pubmed/25117627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-15-81
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