Mimulone-Induced Autophagy through p53-Mediated AMPK/mTOR Pathway Increases Caspase-Mediated Apoptotic Cell Death in A549 Human Lung Cancer Cells

Anticancer properties and mechanisms of mimulone (MML), C-geranylflavonoid isolated from the Paulownia tomentosa fruits, were firstly elucidated in this study. MML prevented cell proliferation in a dose- and time-dependent way and triggered apoptosis through the extrinsic pathway in A549 human lung...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: An, Hyun-Kyu, Kim, Kyoung-Sook, Lee, Ji-Won, Park, Mi-Hyun, Moon, Hyung-In, Park, Shin-Ji, Baik, Ji-Sue, Kim, Cheorl-Ho, Lee, Young-Choon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260910/
https://ncbi.nlm.nih.gov/pubmed/25490748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114607
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