Mimulone-Induced Autophagy through p53-Mediated AMPK/mTOR Pathway Increases Caspase-Mediated Apoptotic Cell Death in A549 Human Lung Cancer Cells

Anticancer properties and mechanisms of mimulone (MML), C-geranylflavonoid isolated from the Paulownia tomentosa fruits, were firstly elucidated in this study. MML prevented cell proliferation in a dose- and time-dependent way and triggered apoptosis through the extrinsic pathway in A549 human lung...

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Publicat a:PLoS One
Autors principals: An, Hyun-Kyu, Kim, Kyoung-Sook, Lee, Ji-Won, Park, Mi-Hyun, Moon, Hyung-In, Park, Shin-Ji, Baik, Ji-Sue, Kim, Cheorl-Ho, Lee, Young-Choon
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260910/
https://ncbi.nlm.nih.gov/pubmed/25490748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114607
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