TRPM2 channel deficiency prevents delayed cytosolic Zn(2+) accumulation and CA1 pyramidal neuronal death after transient global ischemia

Transient ischemia is a leading cause of cognitive dysfunction. Postischemic ROS generation and an increase in the cytosolic Zn(2+) level ([Zn(2+)](c)) are critical in delayed CA1 pyramidal neuronal death, but the underlying mechanisms are not fully understood. Here we investigated the role of ROS-s...

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Publicat a:Cell Death Dis
Autors principals: Ye, M, Yang, W, Ainscough, J F, Hu, X-P, Li, X, Sedo, A, Zhang, X-H, Zhang, X, Chen, Z, Li, X-M, Beech, D J, Sivaprasadarao, A, Luo, J-H, Jiang, L-H
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260752/
https://ncbi.nlm.nih.gov/pubmed/25429618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.494
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