TRPM2-mediated rise in mitochondrial Zn(2+) promotes palmitate-induced mitochondrial fission and pancreatic β-cell death in rodents

Rise in plasma free fatty acids (FFAs) represents a major risk factor for obesity-induced type 2 diabetes. Saturated FFAs cause a progressive decline in insulin secretion by promoting pancreatic β-cell death through increased production of reactive oxygen species (ROS). Recent studies have demonstra...

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Vydáno v:Cell Death Differ
Hlavní autoři: Li, Fangfang, Munsey, Tim S, Sivaprasadarao, Asipu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686341/
https://ncbi.nlm.nih.gov/pubmed/28753206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.118
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