Cafestol overcomes ABT-737 resistance in Mcl-1-overexpressed renal carcinoma Caki cells through downregulation of Mcl-1 expression and upregulation of Bim expression

Although ABT-737, a small-molecule Bcl-2/Bcl-xL inhibitor, has recently emerged as a novel cancer therapeutic agent, ABT-737-induced apoptosis is often blocked in several types of cancer cells with elevated expression of Mcl-1. Cafestol, one of the major compounds in coffee beans, has been reported...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Woo, S M, Min, K-j, Seo, B R, Nam, J-O, Choi, K S, Yoo, Y H, Kwon, T K
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260730/
https://ncbi.nlm.nih.gov/pubmed/25375379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.472
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