A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4

Generation of energy in mitochondria is subjected to physiological regulation at many levels, and its malfunction may result in mitochondrial diseases. Mitochondrial dysfunction is associated with different environmental influences or certain genetic conditions, and can be artificially induced by in...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Evstafieva, A G, Garaeva, A A, Khutornenko, A A, Klepikova, A V, Logacheva, M D, Penin, A A, Novakovsky, G E, Kovaleva, I E, Chumakov, P M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260727/
https://ncbi.nlm.nih.gov/pubmed/25375376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.469
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