Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.

Apolipoprotein B is synthesized by the intestine and the liver in mammals, where it serves as the main structural component in the formation of chylomicrons and very low density lipoproteins, respectively. Apolipoprotein B is also expressed in mammalian fetal membranes. To examine the consequences o...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Farese, R V, Ruland, S L, Flynn, L M, Stokowski, R P, Young, S G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42602/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7878058/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.5.1774
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