SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis

Canonical WNT signaling stabilizes β-catenin to determine cell fate in many processes from development onwards. One of its main roles in skeletogenesis is to antagonize the chondrogenic transcription factor SOX9. We here identify the SOXC proteins as potent amplifiers of this pathway. The SOXC genes...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cell Biol
Egile Nagusiak: Bhattaram, Pallavi, Penzo-Méndez, Alfredo, Kato, Kenji, Bandyopadhyay, Kaustav, Gadi, Abhilash, Taketo, Makoto M., Lefebvre, Véronique
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2014
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259807/
https://ncbi.nlm.nih.gov/pubmed/25452386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201405098
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