SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis

Canonical WNT signaling stabilizes β-catenin to determine cell fate in many processes from development onwards. One of its main roles in skeletogenesis is to antagonize the chondrogenic transcription factor SOX9. We here identify the SOXC proteins as potent amplifiers of this pathway. The SOXC genes...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Bhattaram, Pallavi, Penzo-Méndez, Alfredo, Kato, Kenji, Bandyopadhyay, Kaustav, Gadi, Abhilash, Taketo, Makoto M., Lefebvre, Véronique
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259807/
https://ncbi.nlm.nih.gov/pubmed/25452386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201405098
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