SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis

Canonical WNT signaling stabilizes β-catenin to determine cell fate in many processes from development onwards. One of its main roles in skeletogenesis is to antagonize the chondrogenic transcription factor SOX9. We here identify the SOXC proteins as potent amplifiers of this pathway. The SOXC genes...

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Publicado en:J Cell Biol
Autores principales: Bhattaram, Pallavi, Penzo-Méndez, Alfredo, Kato, Kenji, Bandyopadhyay, Kaustav, Gadi, Abhilash, Taketo, Makoto M., Lefebvre, Véronique
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2014
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259807/
https://ncbi.nlm.nih.gov/pubmed/25452386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201405098
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