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SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis
Canonical WNT signaling stabilizes β-catenin to determine cell fate in many processes from development onwards. One of its main roles in skeletogenesis is to antagonize the chondrogenic transcription factor SOX9. We here identify the SOXC proteins as potent amplifiers of this pathway. The SOXC genes...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4259807/ https://ncbi.nlm.nih.gov/pubmed/25452386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201405098 |
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