LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes

In mammals, cellular swelling activates release of small organic osmolytes, including the excitatory amino acids (EAA) glutamate and aspartate, via a ubiquitously expressed volume-regulated chloride/anion channel (VRAC). Pharmacological evidence suggests that VRAC plays plural physiological and path...

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Bibliographic Details
Published in:J Physiol
Main Authors: Hyzinski-García, María C, Rudkouskaya, Alena, Mongin, Alexander A
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
Subjects:
Neuroscience: Cellular/Molecular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259531/
https://ncbi.nlm.nih.gov/pubmed/25172945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.278887
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