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Molecular composition and heterogeneity of the LRRC8‐containing swelling‐activated osmolyte channels in primary rat astrocytes

KEY POINTS: The volume‐regulated anion channel (VRAC) is a swelling‐activated chloride channel that is permeable to inorganic anions and a variety of small organic molecules. VRAC is formed via heteromerization of LRRC8 proteins, among which LRRC8A is essential, while LRRC8B/C/D/E serve as exchangea...

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Bibliografske podrobnosti
izdano v:J Physiol
Main Authors: Schober, Alexandra L., Wilson, Corinne S., Mongin, Alexander A.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685816/
https://ncbi.nlm.nih.gov/pubmed/28833202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275053
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